Download Stem Cell Engineering: A WTEC Global Assessment by Robert M. Nerem, Jeanne Loring, Todd C. McDevitt, Sean P. PDF

By Robert M. Nerem, Jeanne Loring, Todd C. McDevitt, Sean P. Palecek, David V. Schaffer, Peter W. Zandstra

This publication describes a world evaluate of stem telephone engineering learn, completed via web site visits via a panel of specialists to best institutes, by means of committed workshops. The evaluate made transparent that engineers and the engineering strategy with its quantitative, system-based considering can give a contribution a lot to the growth of stem telephone learn and improvement. The elevated want for advanced computational versions and new, cutting edge applied sciences, comparable to high-throughput screening concepts, organ-on-a-chip versions and in vitro tumor types require an expanding involvement of engineers and actual scientists. also, this booklet will express that even supposing the united states remains to be in a management place in stem phone engineering, Asian international locations comparable to Japan, China and Korea, in addition to ecu nations just like the united kingdom, Germany, Sweden and the Netherlands are swiftly increasing their investments within the box. Strategic partnerships among international locations could lead on to significant advances of the sphere and scalable enlargement and differentiation of stem cells. This research used to be funded through the nationwide technological know-how starting place (NSF), the nationwide Institutes of future health (NIH) and the nationwide Institute of criteria and know-how (NIST).

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1 Schematic of the stem cell microenvironment. Soluble factors, extracellular matrix components, intercellular interactions, and biomechanical cues synergize to regulate cell fate ...................... Fig. 2 Schematic of a high-throughput screen of osteogenic enhancers in human mesenchymal stem cells (hMSCs)..................... Fig. 3 Schematic of combinatorial screening of extracellular matrix (ECM) and growth factor (GF) effects on stem cells .............. Fig. 4 Mapping of contraction stress in cardiomyocytes...............................

These include mechanics, topographical features at multiple size scales, electrostatics, spatiotemporal variation in the presentation of biochemical cues, transport phenomena, and biochemical reaction kinetics. As a result, there are considerable opportunities for physical scientists and engineers to become increasingly involved in stem cell research, not only to gain basic insights into new mechanisms in stem cell biology but to create new technologies to advance this field. Within this report, chapter “High-throughput Screening, Microfluidics, Biosensors, and Real-time Phenotyping” discusses the development of technologies to discover novel signals that regulate stem cell behavior, and chapter “Computational Modeling and Stem Cell Engineering” reviews progress in the development of mathematical models that quantitatively investigate the underlying regulatory mechanisms.

23 Fig. 24 Fig. 25 Fig. 26 Overview of microscale technologies. Dielectrophoresis principles can be used in combination with microfluidics for cell sorting and in combination with microfluidics and microparticles for assembling multicellular constructs.......... Leading researchers and general organization of CiRA ............... Generation of iPS cells for individualized therapy ....................... Use of HLA-matched iPS cells to support factor VIII production .............................................................................

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