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Extra info for The Biochemistry & Medical Significance Of The Flavonoids Havsteen [Article]
5. Transferases No reports on the effects of flavonoids on the action of the transferases are known to the author. 6. Ligases and lyases The ligases use ATP as a substrate and form covalent linkages with it. Due to the structural resemblance, they are potentially inhabitable by flavonoids. However, so far, no such examples have been reported. The remaining class in the international enzyme classification is the lyases. , 1981). 13. , 1998). The roles of flavonoids as plant hormones already have been discussed (see Section 6).
Besides, a considerable, almost constant exposure to flavonoids is unavoidable because they cannot be removed from their main source, the vegetables, beverages, and fruits, which we absolutely need to maintain our health. , by intravenous injection of large amounts. When that is done in the course of a toxicological experiment to assess the safe limits, one observes in rats after 3 weeks of a constant, extremely high flavonoid concentration, morphological changes in the membrane structure of hepatocytes, which lead to cell necrosis and eventually to the death of the animal.
H. Havsteen / Pharmacology & Therapeutics 96 (2002) 67–202 occasionally. At least some flavonoids, therefore, are capable of binding to one or more of the plasma proteins, probably primarily to serum albumin and lipoproteins, since flavonoids are hydrophobic and are transported in bile acid complexes, as well as in chylomicrons. 1. The flavonoids as antigens Flavonoids are only weakly antigenic, but antibodies against flavonoids have been found in human blood. , 1988). However, almost any substance to which we are exposed can give rise to allergy in sensitive persons.