Download The Metabolic Pathway Engineering Handbook: Tools and by Christina Smolke PDF

By Christina Smolke

This moment quantity of the Metabolic Pathway Engineering guide delves into evolutionary instruments and gene expression instruments for metabolic pathway engineering. It covers purposes of rising applied sciences together with contemporary study genome-wide applied sciences, DNA and phenotypic microarrays, and proteomics instruments for experimentally picking out flux via pathways. This quantity additionally appears to be like at rising purposes for generating nice chemical substances, medicines, and replacement fuels. Christine Smolke, who lately constructed a singular method to churn out huge amounts of substances from genetically transformed brewer’s yeast, is considered the most marvelous new minds in biomedical engineering. during this instruction manual, she brings jointly pioneering scientists from dozens of disciplines to supply an entire list of achievement in metabolic pathway engineering. With a wealth of innovative learn and research, this paintings additionally serves as a useful source for these looking to upload their very own contributions. equipped through subject, this 3000 web page reference is accessible as volumes available to buy separately or as a collection.

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Raamsdonk, L. M. et al. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. , 19, 45–50, 2001. 12. , Sherson, S. , and Smith, S. M. Using gene knockouts to investigate plant metabolism. J. Exp. Botany, 52, 1593–1601, 2001. 13. , Loureiro, M. , and Fiehn, O. Differential metabolic networks unravel the effects of silent plant phenotypes. Proc. Natl. Acad. Sci. USA, 101, 7809–14, 2004. 14. Kassen, R. The experimental evolution of specialists, generalists, and the maintenance of diversity.

Evolutionary programming as a platform for in silico metabolic engineering. BMC Bioinformatics, 6, 308, 2005. 39. , Burgard, A. , and Maranas, C. D. OptStrain: a computational framework for redesign of microbial production systems. , 14, 2367–76, 2004. 40. Price, N. , Papin, J. , Schilling, C. , and Palsson, B. O. Genome-scale microbial in silico models: the constraints-based approach. , 21, 162–69, 2003. 41. Covert, M. , Knight, E. , Reed, J. , Herrgard, M. , and Palsson, B. O. Integrating high­throughput and computational data elucidates bacterial networks.

Environmental stress and metabolic stress constitute the two major categories32 of conditions that can be addressed by environmental engineering. Environmental stresses include ­variables external to a cell that affect growth behavior. Examples of environmental stress include antibiotics, toxic chemicals, extreme temperatures, and nutrient limitation. Metabolic stresses occur inside a cell and can include intracellular accumulation of cytotoxic chemicals or increased metabolic burdens often associated with heterologous expression or overexpression of proteins.

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