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By Douglas MacN. Surgenor

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The next modality attempted was the use of defibrinated blood (blood from which the clot has been r e m o v e d ) . Beginning with the work of Pré­ vost and Dumas in 1821, defibrinated blood was used with apparent suc­ cess. Sir Thomas Smith ( 1 8 7 3 ) used defibrinated blood, prepared with a wire eggbeater and sieve, to transfuse a hemorrhaging infant. Attempts have persisted through modern times but it has become evident that the process of defibrination removes much of the protein and cellular content of the blood.

Dudley, H. A. , McNair, T. , Paton, B. C , and Cumming, R. B. (1958). Lancet 1, 294. Eadie, G. , and Brown, I. , Jr. (1955). J. Clin. Invest. 34, 629. Ebaugh, F. , Emerson, C. , and Ross, J. F. (1953). J. Clin. Invest. 32, 1260. Ehrlich, P. (1880). Z. Klin. Med. 1, 553. Ehrlich, P. (1891). " Berlin. Englehardt, J. (1825). " Gott. Epstein, Α. , and Ottenberg, R. (1908). Proc. Ν. Y. Pathol. Soc. 8, 117. Erb, W. Π865). Virchows Arch. 34, 138. Erslev, A. (1953). Blood 8, 349. Erslev, A. (1964). Blood 24, 331.

Pretransfusion Testing Clinical application of laboratory achievements in blood grouping, as in many other fields, occurred much later. Strong emphasis upon the impor­ tance of grouping blood prior to transfusion was made by Hektoen ( 1 9 0 7 ) ; the possibility of eliminating the dangers of blood transfusion by careful donor selection was suggested. Ottenberg and Schultz were proba­ bly the first to make actual use of grouping procedures prior to transfu­ sion. Biological tests were also considered essential in the pretransfusion workup during the early 1900's.

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