Download Tissue Engineering for the Heart: A Case Study Based by Ravi Birla PDF

By Ravi Birla

This ebook covers the basics of tissue engineering for the guts, beginning with the fundamentals of organ new release, sensors in tissue and organ fabrication, and the present cutting-edge in stem mobile engineering for the center. With this starting place in position, the rest chapters specialize in particular points of the cardiovascular approach, beginning with middle muscle, then organic pumps, by means of bioartificial ventricles, and eventually, bioartificial hearts. in the course of the process this booklet, twenty-two in-depth case stories are offered. every one case learn has been chosen to demonstrate particular layout schemes for tissue and organ fabrication. this is often a fantastic booklet for upper-level undergraduate and graduate scholars learning tissue engineering and organ regeneration, specially these all in favour of cardiac regeneration.

This e-book also:

Includes twenty-two case reviews that illustrate particular layout schemes for engineering the heart

Provides open-ended dialogue questions on the finish of every bankruptcy in addition to an in depth reference checklist to inspire extra examine and reading

Covers the fundamentals of organ fabrication in addition to sensor expertise and genetic engineering as they relate to tissue and organ fabrication

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Extra resources for Tissue Engineering for the Heart: A Case Study Based Approach

Example text

There was, however, one interesting addition to the decellularization process—10 % formalin was used for crosslinking of the collagen fibers. This step was added to stabilize the collagen fibers as the decellularization process can have an adverse effect on native ECM, resulting from the use of detergent based solutions. The cross-linking step was included as a novel addition designed to complement the decellularization process and was unique to this study. With cell sourcing and scaffold fabrication complete, the next step in the process is organ fabrication—populating the acellular liver with hepatocytes and stellate cells.

218 Potential clinical application of bioartificial ventricles.  For HLHS patient’s, prenatal echocardiography can be used for diagnosis. Once a patient has been diagnosed with HLHS, umbilical cord MSCs can be harvested at the time of birth and used to support BAVs. Umbilical cord MSCs can be expanded in culture and differentiated to form functional cardiac myocytes. Advances in biomaterial design, synthesis and characterization will be necessary to support scaffold fabrication.

A) Cardioid formation—Cardioids are formed by the spontaneous delamination of a cohesive monolayer of primary cardiac cells on the surface of a carefully controlled cell culture surface. (b) Formation of biological pumps—a tubular graft is positioned at the center of the delaminating cell monolayer. Delamination of the cell monolayer results in the formation of a cell layer on the outer surface of the tubular graft. This process results in the formation of biological pumps . . . . . 180 Muscle cells to fabricate biological pumps.

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