By Ronald Johnston MD
Comprehensive and simple to learn, Weedon’s epidermis Pathology necessities, 2d Edition, via Ronald B. Johnston, MD, offers an outstanding review of key diagnoses in dermatopathology and is perfect for speedy having a look up useful difficulties within the popularity and analysis of pores and skin lesions either clinically and histologically. millions of illustrations, an obtainable structure, and move references to the encyclopedic and authoritative Weedon’s pores and skin Pathology, 4th Edition, make this a must-have reference for pathologists and dermatologists in perform and in training.
- More than 3,300 colour histopathologic and medical images
- Numerous precis tables and diagnostic algorithms
- Outline format
- Expert seek advice™ publication model integrated with buy.
offer whole visible insurance of key diagnostic issues for dermatological entities
advisor you to the main most likely analysis and set of differential diagnoses for various inflammatory and neoplastic epidermis stipulations.
and bullet element style make crucial details for any given lesion effortless to discover and assessment.
This improved booklet adventure allows you to look the entire textual content, figures, and references from the ebook on quite a few units.
- More illustrations
of infrequent stipulations and strange manifestations, and additional entries within the Tumors, Infections, and Infestations sections.
Read or Download Weedon's Skin Pathology Essentials PDF
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Additional info for Weedon's Skin Pathology Essentials
Non-gonococcal urethritis 2. Ocular inflammation 3. Arthritis • Also circinate balanitis, mucosal erosions and red plaques • Keratoderma blennorrhagica ¼ feature of Reiter’s syndrome with pustular-psoriasis-like cutaneous lesions (feet/palms, genitalia, groin) with a crusted erythematous papule/plaque; heals without scarring • Histopathology similar to pustular psoriasis (psoriasiform epidermal hyperplasia with thick horny/stratum corneum layer); thick parakeratotic scale crust (often detaches) 57 58 CHAPTER 4 • PSORIASIFORM REACTION PATTERN Name Predilection and Clinical Key Features Histopathology Pityriasis rubra pilaris (PRP) • Unknown etiology • “Psoriasiform þ seborrheic dermatitits þ keratosis pilaris-like” • “Checkerboard” ¼ alternating orthokeratosis and parakeratosis in vertical and horizontal directions, forms collarette around follicular ostia; acanthosis; hypergranulosis; follicular plugging and parakeratotic lipping of follicle; perivascular infiltrate, mainly lymphocytes (occasional eosinophils and plasma cells) • “Shoulder parakeratosis” (similar to seborrheic dermatitis) • Follicular papules with central keratin plug; “islands of sparing”; palmoplantar keratoderma; may become erythrodermic • Clinically similar to phrynoderma (vitamin A deficiency) • Clinical classifications: Type I/classic adult (most common): • “Islands of sparing,” waxy PPK; usually clear in 3 years Type II/atypical adult: • Coarse, lamellated PPK, ichthyosiform scale on legs, possibly alopecia; chronic course Type III/classic juvenile: • Similar to type I, but in children Type IV/circumscribed juvenile (most common juvenile): • Elbows and knees; variable course Type V/atypical juvenile: • Scleroderma-like on hands/feet; majority of familial cases; chronic course • Note: the “P” alternating with “R” in “PRP” helps in remembering the alternating ortho- and parakeratosis!
G. maculopapular, psoriasiform, lichenoid, follicular, pustulas, etc. e. stratum corneum) • Well-circumscribed, erythematous patches with silvery white scale; Auspitz’s sign (bleeding if remove scale); arthritis • Woronoff ring ¼ white halo around psoriatic plaque due to prostaglandin E2 (PGE2), especially with treatment Basic science of psoriasis • • • • • • AIDS-associated psoriasiform dermatitis Th17 > Th1 immune response (IL23 > TNF-a) Increased K6, K16, K17; unique cells with K6 and K10 expression More CD4 cells in dermis; more CD8 cells in epidermis Susceptibility gene ¼ PSOR1 (30%); usually RF negative (80%) Epidermal turnover ¼ 3–4 days vs.
359 for more information) Rowell syndrome • Lupus patients who develop annular, erythemalike lesions • LE þ EM • RF positive, speckled ANA • LE þ EM-like Other lupus variants • DIF ¼ IgG, IgM, etc. e. e. ) • Possible positive autoantibodies: • ANA • anti-Jo-1 (antihistidyl transfer RNA synthetase) ¼ correlate pulmonary fibrosis, Raynaud’s and polyarthritis • anti-Mi-2 ¼ correlate to classic DM (shawl sign, cuticle change, Gottron’s papules/sign, favorable diagnosis) • anti-SRP ¼ correlate cardiac disease, poor prognosis • anti- Ku ¼ correlate sclerodermatomyositis • anti-PL 12 ¼ correlate pulmonary disease • DIF usually negative or granular IgG or C5b-9 along BMZ • Gottron’s papules (above) show mild hyperkeratosis, some acanthosis, and basal vacuolar changes.